Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice

Yoshihiro Matsushima · Osamu Shirota · Ruri Kikura‐Hanajiri · Yukihiro Goda · Fumio Eguchi

71 citations0/0 files storedBioscience Biotechnology and Biochemistry

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Psychedelics and Drug Studies Neurotransmitter Receptor Influence on Behavior Obsessive-Compulsive Spectrum Disorders

Abstract

Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.

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2007Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior 2006Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder 2003Concise Large-Scale Synthesis of Psilocin and Psilocybin, Principal Hallucinogenic Constituents of “Magic Mushroom”1987Relief of obsessive-compulsive symptoms by LSD and psilocin 2005SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist

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