Cortical anomalies in brains of New Zealand mice: a neuropathologic model of dyslexia?

Gordon F. Sherman · Albert M. Galaburda · Norman Geschwind

80 citations0/0 files storedProceedings of the National Academy of Sciences

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Reading and Literacy Development Hemispheric Asymmetry in Neuroscience Genetics and Neurodevelopmental Disorders

Abstract

Cortical anomalies have been reported in the brains of dyslexic individuals. In addition, dyslexic and left-handed individuals have a higher than expected rate of some immune-related diseases. The possible association between immune and cerebrocortical pathology was investigated in the immune-defective New Zealand Black mouse and its hybrid with the New Zealand White mouse. Structural anomalies similar to those present in the dyslexic brain were seen in the brains of these mice.

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References

1985Developmental dyslexia: Four consecutive patients with cortical anomalies 1979Cytoarchitectonic abnormalities in developmental dyslexia: A case study

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1993Neuro Anatomic Basis of Developmental Dyslexia 2003Neural Mechanisms of Language-Based Learning Impairments: Insights from Human Populations and Animal Models 1994Developmental dyslexia and animal studies: at the interface between cognition and neurology 2018The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on

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