Articlebronze2003

Association analysis of the catechol‐o‐methyltransferase (COMT ), serotonin transporter (5‐HTT ) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive‐compulsive disorder

Ivanor Meira‐Lima · Roseli Gedanke Shavitt · Karen Miguita · E. Ikenaga · Eurı́pedes Constantino Miguel · Homero Vallada

106 citations0/0 files storedGenes Brain & Behavior

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Obsessive-Compulsive Spectrum Disorders Schizophrenia research and treatment Neurotransmitter Receptor Influence on Behavior

Abstract

Family and twin studies have supported a strong genetic factor in the etiology of obsessive-compulsive disorder (OCD), although the precise mechanism of inheritance is unclear. Clinical and pharmacological studies have implicated the serotonergic and dopaminergic systems in disease pathogenesis. In this cross-sectional study, we have examined the allelic and genotypic frequencies of a Val-158-Met substitution in the COMT gene, a 44-base pair (bp) length variation in the regulatory region of the serotonin transporter gene (5-HTTLPR) and the T102C and C516T variants in the serotonin receptor type 2A (5HT2A) gene in 79 OCD patients and 202 control subjects. There were no observed differences in the frequencies of allele and genotype between patients and control groups for the COMT, the 5HTTLPR and the T102C 5HT2A gene polymorphisms. In contrast, a statistically significant difference between OCD patients and controls was observed on the genotypic distribution (chi(2) = 16.7, 2df, P = 0.0002) and on the allelic frequencies (chi(2) = 15.8, 1df, P = 0.00007) for the C516T 5HT2A gene polymorphism. The results suggest that the C516T variant of the 5HT2A gene may be one of the genetic risk factors for OCD in our sample. However, further studies using larger samples and family based methods are recommended to confirm these findings.

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References

1989The Yale-Brown Obsessive Compulsive Scale 1994The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency 1995A family study of obsessive-compulsive disorder 2000A Family Study of Obsessive-compulsive Disorder 1997Genotype determining low catechol- O -methyltransferase activity as a risk factor for obsessive-compulsive disorder 1999Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder 2003Obsessions and compulsions in anorexia nervosa subtypes 1998Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder

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2010Genetics of Obsessive-Compulsive Disorder 2009Overview of genetics and obsessive–compulsive disorder 2007Association Studies of Serotonin System Candidate Genes in Early-onset Obsessive-Compulsive Disorder 2007Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive–compulsive disorder 2006The Current Status of Association Studies in Obsessive-Compulsive Disorder

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