Anorexia nervosa and food avoidance emotional disorder.

J F Higgs · Ian Michael Goodyer · Jillian M. Birch

101 citations0/0 files storedArchives of Disease in Childhood

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Eating Disorders and Behaviors Multiple Sclerosis Research Studies Functional Brain Connectivity Studies

Abstract

Background: The cerebellum is of potential interest for understanding adaptive responses in motor control in patients with multiple sclerosis because of the high intrinsic synaptic plasticity of this brain region. Objective: To assess the relative roles of interactions between the neocortex and the cerebellum using measures of functional connectivity. Methods: A role for altered neocortical–cerebellar functional connectivity in adaptive responses to injury from multiple sclerosis was tested using 1.5 T functional magnetic resonance imaging (fMRI) during figure writing with the dominant right hand in patients with predominantly early relapsing-remitting multiple sclerosis. Results: Patients (n = 14) showed a more bihemispheric pattern of activation in motor cortex than healthy controls (n = 11). Correlations between task related signal changes in neocortical and cerebellar regions of interest were used as a measure of functional connectivity. Healthy controls showed strong functional connectivity between the left motor cortex and the right cerebellar dentate nucleus. Significant connectivity between the left primary motor cortex and the right dentate was not found in patients. However, patients had significant connectivity between the left premotor neocortex and the ipsilateral (left) cerebellar cortex (crus I), which was not found in healthy controls. Conclusions: Changes in apparent cerebellar–neocortical functional connectivity may mediate potentially adaptive changes in brain motor control in patients with multiple sclerosis. Similar changes in the cerebellum and premotor cortex have been reported in the healthy brain during motor learning, suggesting that common mechanisms may contribute to normal motor learning and motor recovery after injury from multiple sclerosis.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 101 citations exist upstream.

References

1975Value of family background and clinical features as predictors of long-term outcome in anorexia nervosa: four-year follow-up study of 41 patients 1980Outcome of Anorexia Nervosa 1983Screening for abnormal eating attitudes and psychiatric morbidity in an unselected population of 15-year-old schoolgirls 1987Early onset anorexia nervosa.1988Long term follow up of patients with early onset anorexia nervosa.1968A STUDY OF ANOREXIA NERVOSA IN YOUNG GIRLS 1986PRE-PUBERTAL ANOREXIA NERVOSA: A RETROSPECTIVE CONTROLLED STUDY

Cited by

2018Outcome of childhood anorexia nervosa—The results of a five‐ to ten‐year follow‐up study 2005Reliability and validity of the child version of the eating disorder examination: A preliminary investigation 2018Impact of expanded diagnostic criteria for avoidant/restrictive food intake disorder on clinical comparisons with anorexia nervosa 2004Post-Surgical Refusal to Eat: Anorexia Nervosa, Bulimia Nervosa or a New Eating Disorder? A Case Series 2000Transtornos alimentares 1996An eight-year follow-up: Outcome from adolescent compared to adult onset anorexia nervosa

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.