Article1996

Fluvoxamine Attenuates Panic Induced by 35% CO2 Challenge

Henk Pols · Roos C. Hauzer · Jaap A.M.J. Meijer · Kees Verburg · Eric J.L. Griez

45 citations0/0 files storedThe Journal of Clinical Psychiatry

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neurotransmitter Receptor Influence on Behavior Treatment of Major Depression

Abstract

BACKGROUND: The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-III-R panic disorder with agoraphobia. METHOD: The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment. RESULTS: The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment. CONCLUSION: The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.

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