Early Adverse Experiences in Schizophrenia and Unipolar Depression

Ivo Alex Rubino · Roberta Croce Nanni · Alberto Siracusano

69 citations0/0 files storedThe Journal of Nervous and Mental Disease

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Child Abuse and Trauma Schizophrenia research and treatment Psychoanalysis and Psychopathology Research

Abstract

To study the prevalence of early adversities in schizophrenia and unipolar depression, 2 groups of consecutive adult-onset inpatients with DSM-IV diagnoses of schizophrenia (n = 173) and unipolar depression (n = 305) were compared with an unscreened control group of volunteers from the general population (n = 310), with respect to their association with 4 types of childhood abuse and with early parental adversities (discord, separation, death, psychiatric caseness). Compared with general population, most types of early adversities (except sexual abuse and parental death) were significantly associated with both clinical groups. Compared with depression, all early adversities with the same 2 exceptions were significantly associated with schizophrenia; both frequency of abuse and number of types of abuse increased the risk of schizophrenia in a dose-response pattern, suggesting causality. These findings stress the role of social developmental factors in the etiology of schizophrenia.

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References

2005Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications 1997Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey 2000Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women 2007A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up 1999Childhood Abuse and Neglect: Specificity of Effects on Adolescent and Young Adult Depression and Suicidality 1996Childhood Sexual Abuse and Psychiatric Disorder in Young Adulthood: II. Psychiatric Outcomes of Childhood Sexual Abuse 2003Childhood abuse as a risk factor for psychotic experiences 2002Association Between Self-reported Childhood Sexual Abuse and Adverse Psychosocial Outcomes

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