Review2013

Childhood maltreatment and inflammatory markers: a systematic review

Roberta Paula Schell Coelho · Thiago Wendt Viola · Consuelo Walss‐Bass · Elisa Macedo Brietzke · Rodrigo Grassi‐Oliveira

425 citations0/0 files storedActa Psychiatrica Scandinavica

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Child Abuse and Trauma Child Welfare and Adoption Stress Responses and Cortisol

Abstract

OBJECTIVE: Childhood maltreatment (CM) has been associated with several diseases in adult life, including diabetes, obesity and mental disorders. Inflammatory conditions have been postulated as possible mediators of this relationship. The aim was to conduct a systematic review regarding the association between CM and inflammatory markers in adulthood. METHOD: A literature search of the PubMed, ISI, EMBASE and PsychINFO databases was conducted. The key terms used were as follows: 'Child Maltreatment', 'Childhood Trauma', 'Early Life Stress', 'Psychological Stress', 'Emotional Stress', 'Child Abuse' and 'Child Neglect'. They were cross-referenced separately with the terms: 'C-reactive Protein (CRP)', 'Tumor Necrosis Factor', 'Cytokine', 'Interleukin', 'Inflammatory' and 'Inflammation'. RESULTS: Twenty articles remained in the review after exclusion criteria were applied. Studies showed that a history of CM was associated with increased levels of CRP, fibrinogen and proinflammatory cytokines. Increased levels of circulating CRP in individuals with a history of CM were the most robust finding among the studies. Data about anti-inflammatory mediators are still few and inconsistent. CONCLUSION: Childhood maltreatment is associated with a chronic inflammatory state independent of clinical comorbidities. However, studies are heterogeneous regarding CM assessment and definition. Important methodological improvements are needed to better understand the potential impact of CM on inflammatory response.

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References

1998Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults 2003Development and validation of a brief screening version of the Childhood Trauma Questionnaire 2011The Lifelong Effects of Early Childhood Adversity and Toxic Stress 2011Adverse childhood experiences, allostasis, allostatic load, and age-related disease 2007Childhood maltreatment predicts adult inflammation in a life-course study 2009Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease 2009How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment 2009A Meta-Analytic Review of the Effects of Childhood Abuse on Medical Outcomes in Adulthood

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