Article2000

Is the 5-HT1Dβ Receptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?

Emanuela Mundo · Margaret Anne Richter · Fariba Sam · Fabio M. Macciardi · James L. Kennedy

103 citations0/0 files storedAmerican Journal of Psychiatry

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Neurotransmitter Receptor Influence on Behavior

Abstract

OBJECTIVE: Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)(1Dbeta) autoreceptor, modifies OCD symptoms. The aim of this study was to investigate the presence of linkage disequilibrium between the 5-HT(1Dbeta) receptor gene, which has a variant caused by a silent G to C substitution at nucleotide 861 of the coding region, and OCD. METHOD: DNA was collected from 67 probands who met DSM-IV criteria for OCD and from their living parents or siblings. Transmission Disequilibrium Test/sib-Transmission Disequilibrium Test analyses were then conducted with the DNA data. RESULTS: Thirty-two families were informative for the analysis, which showed a preferential transmission of the G allele to the affected subjects. CONCLUSIONS: If the results are confirmed, there may be important implications for the 5-HT(1Dbeta) receptor gene in the pathogenesis and treatment of OCD.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 103 citations exist upstream.

References

1989The Yale-Brown Obsessive Compulsive Scale 1995Efficacy and Tolerability of Serotonin Transport Inhibitors in Obsessive-compulsive Disorder 1998Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder 1997Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene

Cited by

2008Chronic Reductions in Serotonin Transporter Function Prevent 5-HT1B-Induced Behavioral Effects in Mice 20025HT1Dβ Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study 2009Overview of genetics and obsessive–compulsive disorder 2003Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder 2001Neurobiology and Clinical Pharmacology of Obsessive-Compulsive Disorder 2007Association Studies of Serotonin System Candidate Genes in Early-onset Obsessive-Compulsive Disorder 2003Genetics of obsessive-compulsive disorders: new findings and challenges 2002Association between the dopamine receptor D4 (DRD4) gene and obsessive‐compulsive disorder

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.