Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

Alicja Lerner · Anto I. Bagic · Eilis Ann Boudreau · Takashi Hanakawa · Fernando Pagán · Zoltan K. Mari +6 more

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Obsessive-Compulsive Spectrum Disorders Neural and Behavioral Psychology Studies Neurological disorders and treatments

Abstract

OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. METHODS: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.

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References

1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 1982Insula of the old world monkey. III: Efferent cortical output and comments on function 2003Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome 1998A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome 2006Neural correlates of tic generation in Tourette syndrome: an event-related functional MRI study 2000A Functional Neuroanatomy of Tics in Tourette Syndrome 2003Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndrome 2005Monitoring and Staging Human Sleep

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2009Cerebellar morphology in Tourette syndrome and obsessive‐compulsive disorder 2017Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome 2015Pathophysiology of tic disorders 2012Deep Brain Stimulation for Tourette Syndrome: Target Selection 2011Abnormal metabolic brain networks in Tourette syndrome

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