Mood change during weight restoration in patients with anorexia nervosa

Katharine G. Meehan · Katharine L. Loeb · Christina A. Roberto · Evelyn Attia

85 citations0/0 files storedInternational Journal of Eating Disorders

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Eating Disorders and Behaviors Nutrition, Health and Food Behavior Psychological Treatments and Disorders

Abstract

OBJECTIVE: Although depression is known to co-occur with anorexia nervosa (AN), there are few clear studies of mood in the context of weight gain treatment without the use of medication. METHOD: Twenty-one patients admitted consecutively to an inpatient clinical research unit normalized weight to at least 90% of ideal body weight (IBW). Depression was assessed at admission and weight normalization (pre-discharge) with the Beck Depression Inventory (BDI). RESULTS: Multivariate F tests showed BDI scores to be significantly improved across these two time points (BMI: F(2,20) = 166.58, p = 0.000; BDI: F(2,19) = 22.64, p = 0.000). Moreover, improvement in mood was also evident at partial weight restoration (80% IBW). CONCLUSION: Patients with AN undergoing nutritional rehabilitation and psychotherapy on an inpatient unit present with significant depressive symptoms as measured by the BDI, and, with weight restoration, demonstrate statistically significant improvement in mood symptoms without the use of adjunctive medication. Data at partial weight restoration suggest that these results cannot be explained by improved mood related to anticipation of discharge.

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References

1960A RATING SCALE FOR DEPRESSION 2013Structured Clinical Interview for DSM-IV (SCID)2000The use of the Beck Depression Inventory to screen for depression in the general population: a preliminary analysis 1992Psychiatric Comorbidity in Treatment-Seeking Anorexics and Bulimics 1998Does Fluoxetine Augment the Inpatient Treatment of Anorexia Nervosa?1997Relationship of depression, anxiety, and obsessionality to state of illness in anorexia nervosa 1996COMORBIDITY AND OUTCOME IN EATING DISORDERS 2017Structured Clinical Interview for DSM-IV (SCID)

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2008Treatment goal weight in adolescents with anorexia nervosa: Use of BMI percentiles 2012Depression, anxiety and obsessive–compulsive symptoms in relation to nutritional status and outcome in severe anorexia nervosa 2016Predictors of outcomes in outpatients with anorexia nervosa – Results from the ANTOP study

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