Articlegreen2005

Adding quetiapine to SRI in treatment-resistant obsessive???compulsive disorder: a randomized controlled treatment study

Naomi Anne Fineberg · T. Sivakumaran · Tim M. Gale

105 citations0/0 files storedInternational Clinical Psychopharmacology

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Abstract

This study aimed to determine the efficacy and tolerability of adding quetiapine to a serotonin reuptake inhibitor in treatment-resistant obsessive-compulsive disorder (OCD). Twenty-one adult treatment-resistant OCD patients were randomized to 16 weeks of augmentation with either quetiapine (n = 11) or placebo (n = 10). Patients with significant comorbidities, including tic-spectrum disorders, were not included. The treatment was well tolerated, with only one premature dropout in each treatment-group. The primary analysis showed that individuals in the quetiapine-treated group showed a 14% mean improvement in baseline Yale-Brown Obsessive-Compulsive Scale scores at study endpoint compared with a 6% improvement in those treated with placebo, but this difference did not reach statistical significance (F<1). Three patients treated with quetiapine met criteria for clinical response, compared to one patient who was treated with placebo. Larger studies are needed to explore the efficacy of second generation antipsychotics, such as quetiapine, when used as adjunct treatment in resistant OCD.

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References

1979A New Depression Scale Designed to be Sensitive to Change 1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 2000A Double-blind, Placebo-Controlled Study of Risperidone Addition in Serotonin Reuptake Inhibitor–Refractory Obsessive-compulsive Disorder 2002Treatment non-response in OCD: methodological issues and operational definitions 2012Evidence-based pharmacotherapy of obsessive-compulsive disorder 2004Augmentation of Serotonin Reuptake Inhibitors in Refractory Obsessive-Compulsive Disorder Using Adjunctive Olanzapine 2005Evidence-based pharmacotherapy of obsessive–compulsive disorder 2003Risperidone augmentation in treatment-resistant obsessive–compulsive disorder: a double-blind, placebo-controlled study

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2014Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders 2008World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision 2009Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review 2006

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