Article2002

Comparison of Response to a Selective Serotonin Reuptake Inhibitor in Children, Adolescents, and Adults with Posttraumatic Stress Disorder

Soraya Seedat · Dan Joseph Stein · Carl Ziervogel · Tessa C. Middleton · Deborah Kaminer · Robin Alexander Emsley +1 more

117 citations0/0 files storedJournal of Child and Adolescent Psychopharmacology

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Posttraumatic Stress Disorder Research Psychoanalysis and Psychopathology Research Child Abuse and Trauma

Abstract

BACKGROUND: Although the pathophysiology of posttraumatic stress disorder (PTSD) is considered multifactorial, empirical evidence suggests that serotonergic dysregulation may characterize the disorder. The efficacy of the selective serotonin reuptake inhibitors (SSRIs) in treating essential symptoms (re-experiencing, avoidance, numbing, hyperarousal) in both adults and children is likely to involve potentiation of this neurotransmitter. OBJECTIVE: This study compared outcome in an 8-week open trial of citalopram (an SSRI) in children/adolescents and adults with a Diagnostic and Statistical Manual of Mental Disorders (4th ed.) diagnosis of PTSD. METHODS: Twenty-four children/adolescents and 14 adults assessed for PTSD severity at baseline were followed up on citalopram treatment (20-40 mg/day) at two-weekly intervals over 8 weeks. The Clinician-Adminstered PTSD Scale (CAPS) and the Clinical Global Improvement Scale (CGI) were used as outcome measures. RESULTS: Although there were no significant differences in outcome measures between children/adolescents (n = 24) and adults (n = 14), both groups had significant reductions in mean CAPS total scores, symptom cluster scores, and CGI ratings at endpoint. CONCLUSION: Although the SSRIs have established efficacy and safety in the treatment of adult PTSD, literature on their use in child and adolescent PTSD is sparse. Controlled data are needed to support the clinical perception that SSRIs are agents of choice in the treatment of pediatric PTSD.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 117 citations exist upstream.

References

1995Posttraumatic Stress Disorder in the National Comorbidity Survey 1997Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data 1995The development of a Clinician-Administered PTSD Scale 1990A clinician rating scale for assessing current and lifetime PTSD. The CAPS-1 1998Psychological predictors of chronic posttraumatic stress disorder after motor vehicle accidents.2000Comorbidity of psychiatric disorders and posttraumatic stress disorder.2004Review of Child and Adolescent Refugee Mental Health 2001Fluvoxamine for the Treatment of Anxiety Disorders in Children and Adolescents

Cited by

2010Psychopharmacologic Treatment of Posttraumatic Stress Disorder in Children and Adolescents 2006Posttraumatic Stress Disorder: Memory and Learning Performance in Children and Adolescents 2004Current Concepts in Pharmacotherapy for Posttraumatic Stress Disorder 2015Emotion Regulatory Brain Function and SSRI Treatment in PTSD: Neural Correlates and Predictors of Change 2003

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.