Association of low serum total cholesterol with major depression and suicide

Timo Partonen · Jari K. Haukka · Jarmo R. K. Virtamo · Philip R. Taylor · Jouko K Lönnqvist

221 citations0/0 files storedThe British Journal of Psychiatry

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Suicide and Self-Harm Studies Lipoproteins and Cardiovascular Health Treatment of Major Depression

Abstract

BACKGROUND: It has been suggested that low serum total cholesterol is associated with an increased risk of suicide. AIMS: To study the association between serum total cholesterol, depression and suicide using versatile, prospective data. METHOD: A total of 29,133 men aged 50-69 years were followed up for 5-8 years. Baseline blood samples were analysed for serum total and high-density lipoprotein cholesterol concentrations. Self-reported depression was recorded, data on hospital treatments due to depressive disorders were derived from the National Hospital Discharge Register and deaths from suicide were identified from death certificates. RESULTS: Low serum total cholesterol was associated with low mood and subsequently a heightened risk of hospital treatment due to major depressive disorder and of death from suicide. CONCLUSIONS: Our results suggest that low serum total cholesterol appears to be associated with low mood and thus to predict its serious consequences.

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References

1997Suicide as an outcome for mental disorders 1997Case-finding instruments for depression 1992Low serum cholesterol and suicide

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2009Suicide neurobiology 2015Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies 2002Serum Cholesterol Levels and Suicide: A Meta‐Analysis 2003Clinical application of low serum cholesterol as an indicator for suicide risk in major depression 2014Serum lipids, recent suicide attempt and recent suicide status in patients with major depressive disorder 2002Mental Health Literacy of those with Major Depression and Suicidal Ideation: An Impediment to Help Seeking 2007Combined biological tests for suicide prediction 2007Cholesterol and suicide attempts: A prospective study of depressed inpatients

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