Article2005

Amygdala reactivity to emotional faces predicts improvement in major depression

Turhan Canli · Rebecca E. Cooney · Philippe R. Goldin · Maulik P. Shah · Heidi Sivers · Moriah E. Thomason +3 more

174 citations0/0 files storedNeuroreport

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies Treatment of Major Depression

Abstract

Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.

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References

1960A RATING SCALE FOR DEPRESSION 2012Cognitive Therapy for Depression 1980Cognitive Therapy of Depression 2001Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study 2004Attentional Biases for Negative Interpersonal Stimuli in Clinical Depression.2002Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals 2002Behavioral activation and inhibition systems and the severity and course of depression.2002Sadness and amusement reactivity differentially predict concurrent and prospective functioning in major depressive disorder.

Cited by

2010Ambulatory emotional reactivity to negative daily life events predicts remission from major depressive disorder 2008Amygdala responses to emotional faces in twins discordant or concordant for the risk for anxiety and depression 2017Blunted amygdala activity is associated with depression severity in treatment-resistant depression 2014Physiological and behavioral indices of emotion dysregulation as predictors of outcome from cognitive behavioral therapy and acceptance and commitment therapy for anxiety

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