Article2008

Corpus Callosum in Patients with Obsessive-Compulsive Disorder: Diffusion-Tensor Imaging Study

Yukiko Saito · Kenji Nobuhara · Gaku Okugawa · Katsunori Takase · Tatsuya Sugimoto · Chiho Ueno +6 more

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Obsessive-Compulsive Spectrum Disorders Neurological disorders and treatments Advanced Neuroimaging Techniques and Applications

Abstract

PURPOSE: To prospectively examine microstructural white matter abnormalities in the corpus callosum (CC) of patients with obsessive-compulsive disorder (OCD), as compared with control subjects, and to investigate the relationship between diffusion-tensor (DT) imaging measures of the CC region and clinical symptoms of OCD. MATERIALS AND METHODS: Institutional review board approval was obtained, and each participant--or the participant's parent(s)--provided written informed consent. Sixteen patients with OCD (seven male, nine female; mean age, 28.7 years +/- 9.8 [standard deviation]) and 16 matched healthy volunteers (control subjects) (seven male, nine female; mean age, 29.9 years +/- 9.0) were examined. Mean diffusivity and fractional anisotropy (FA) were measured in five subdivisions of the CC. The paired t test was performed to compare the mean diffusivity or the FA in CC regions between the patients with OCD and the control subjects. RESULTS: There were no significant differences (rostrum, P = .15; genu, P = .88; rostral body, P = .12; isthmus, P = .77; splenium, P = .88) in mean diffusivity between the patients with OCD and the healthy volunteers. A significant reduction in FA was observed in the rostrum of the CC in patients with OCD compared with the rostral FA in the control subjects (P < .001). Higher FA in only the rostrum correlated significantly with lower Yale-Brown obsessive-compulsive scale score (r = -0.72, P = .002). CONCLUSION: Study results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and indicate that the orbitofrontal circuit influences symptom severity in patients with OCD.

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References

1992Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder 1994Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15—Labeled Carbon Dioxide and Positron Emission Tomography 1987Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder 1989Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder 1992The Epidemiology and Differential Diagnosis of Obsessive-Compulsive Disorder 1994The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group.1998Cognitive Deficits in Obsessive–Compulsive Disorder on Tests of Frontal–Striatal Function 2005White Matter Abnormalities in Obsessive-compulsive Disorder

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2010Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder 2011Microstructural Brain Abnormalities in Patients with Obsessive-Compulsive Disorder: Diffusion-Tensor MR Imaging Study at 3.0 T 2012White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder 2012Widespread changes of white matter microstructure in obsessive–compulsive disorder: Effect of drug status

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