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Researchers have pointed out the difficulties that high school students have in understanding meiosis and the infrequency with which they acknowledge the conceptual relationships between meiosis and classical genetics, particularly when solving genetics problems. The research described in this article paints a different picture of students' reasoning with meiosis as they solved complex, computergenerated genetics problems, some of which required them to revise their understanding of meiosis in response to anomalous data. Details are presented of the ways students used their knowledge of meiosis to recognize anomalous data, to generate hypotheses as part of the revision of explanatory models, and to assess these hypotheses. The findings from this research, contrary to most reports in the literature, suggest that students are able to develop rich understanding of meiosis and can utilize that knowledge to solve genetics problems.
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