Suicidal behaviour in youths with depression treated with new-generation antidepressants

Bernadka Dubicka · Sarah Hadley · Chris Roberts

123 citations0/0 files storedThe British Journal of Psychiatry

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Suicide and Self-Harm Studies Treatment of Major Depression Bipolar Disorder and Treatment

Abstract

BACKGROUND: Concern exists that antidepressants can cause suicidality in youths with depression. AIMS: To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants. METHOD: A meta-analysis was carried out to calculate odds ratios for the combined data. RESULTS: Self-harm or suicide-related events occurred in 71 of 1487 (4.8%) of depressed youths treated with antidepressants v. 38 of 1254 (3.0%) of those given placebo (fixed effects odds ratio 1.70, 95% CI 1.13-2.54, P=0.01). There was a trend for individual suicidal thoughts, attempts and self-harm to occur more often in youths taking antidepressants than in those given placebo, but none of these differences was statistically significant. CONCLUSIONS: Antidepressants may cause a small short-term risk of self-harm or suicidal events in children and adolescents with major depressive disorder.

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References

1986Meta-analysis in clinical trials 2000Methods for Meta-Analysis in Medical Research 1996Psychiatric Diagnosis in Child and Adolescent Suicide 2006National Collaborating Centre for Mental Health 2005Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials 1991Adult outcomes of childhood and adolescent depression.2005Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review 1993Childhood Depression and Risk of Suicide: A Preliminary Report of a Longitudinal Study

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