Article1998

Lowering the hemoglobin cutoff for female plateletpheresis donors

Jean L. Fraser · A. Whatmough · Lynne Uhl · Margot S. Kruskall

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Blood donation and transfusion practices Clinical Laboratory Practices and Quality Control Blood transfusion and management

Abstract

BACKGROUND: The standards of the American Association of Blood Banks describe a minimum hemoglobin level of 12.5 g per dL for apheresis donors. Until 1995, the authors' institution accepted occasional platelet donors with a lower minimum hemoglobin (11.5 g/dL), if accompanied by medical director approval. STUDY DESIGN: All donation records from a 6-month period before 1995 were retrospectively reviewed to determine whether this lower hemoglobin cutoff adversely affected either the safety of the platelet donation process or donors' subsequent hemoglobin levels. RESULTS: Of 450 donations, 56 (12%, Group 1) were from donors with hemoglobin concentrations between 11.5 and 12.4 g per dL (2 donations from 1 man; 54 donations from 45 women). The remaining 394 donations (88%, Group 2) came from donors with hemoglobin concentrations > or = 12.5 g per dL (216 donations from 118 men; 178 donations from 119 women). The frequency of donor reactions was acceptable (Group 1, 11%; Group 2, 6%); 2 percent of donations by Group 1 donors and 1 percent by Group 2 donors were terminated because of these reactions. Of 46 donors in Group 1, 30 returned to donate platelets again at a later time; at least once, 23 (77%) had a hemoglobin > or = 12.5 g per dL. Ten donors in Group 1 returned for additional donations within 56 days; no meaningful decrease in hemoglobin levels occurred. A hemoglobin cutoff of 12.5 g per dL during the study period would have excluded 1 percent of platelet donations by men and 23 percent by women. CONCLUSION: The data demonstrate that the lower hemoglobin cutoff of 11.5 g per dL is a safe and relevant threshold for accepting female plateletpheresis donors and would allow more participation by women in blood donor programs.

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1977Standards for blood banks and transfusion services.1994Basic principles and practice 1987Temporary deferral and donor return

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2007Frequent platelet apheresis donations in volunteer donors with hemoglobin <125g/l are safe and efficient 2002Volunteer Donor Apheresis 2014Donor Deferral Characteristics for Plateletpheresis at a Tertiary Care Center in India- A Retrospective Analysis 2020Prevalence, risk factors, and ferritin testing to mitigate iron depletion in male plateletpheresis donors 2012Switching iron‐deficient whole blood donors to plateletpheresis 2016A Retrospective Analysis of Apheresis Donor Deferral and Adverse Reactions at a Tertiary Care Centre in India 2017Analysis of plateletpheresis donor deferral rate, characteristics, and its preventability

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