Articlehybrid1985

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

Edward A. Sausville · D Carney · James F. Battey

338 citations0/0 files storedJournal of Biological Chemistry

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Neuroendocrine regulation and behavior Neuropeptides and Animal Physiology Cardiovascular, Neuropeptides, and Oxidative Stress Research

Abstract

The human genes for prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NPII) and prepro-oxytocin-neurophysin I (prepro-OT-NPI) were cloned from a human genomic library and the nucleotide sequence of both genes was determined. The two genes are similar in their intron-exon structure, linked together with 12 kilobases intervening, and transcribed from opposite DNA strands. A human small cell lung cancer cell line, H378, produces significant quantities of pre-pro-AVP-NPII mRNA using a transcription unit predicted from the genomic DNA sequence. Despite the proximity of the actively transcribed prepro-AVP-NPII gene, transcription of prepro-OT-NPI is not detected in this cell line.

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1982Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursor 1984Structure and comparison of the oxytocin and vasopressin genes from rat.

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2002The social deficits of the oxytocin knockout mouse 1991Chronic ethanol ingestion decreases vasopressin mRNA in hypothalamic and extrahypothalamic nuclei of mouse brain 1986Glucocorticoid sensitivity of vasopressin mRNA levels in the paraventricular nucleus of the rat.1986Regulation of vasopressin gene expression in rat hypothalamic neurons. Response to osmotic stimulation.1988Oxytocin and vasopressin gene expression during gestation and lactation 1995Structural and functional evolution of the vasopressin/oxytocin superfamily: vasopressin-related conopressin is the only member present in Lymnaea, and is involved in the control of sexual behavior 1990Structure of mouse vasopressin and oxytocin genes 1988Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons

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