Prediction of low haemoglobin levels in whole blood donors

A. Mireille Baart · Wim L.A.M. de Kort · Karel G.M. Moons · Yvonne Vergouwe

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Blood donation and transfusion practices Iron Metabolism and Disorders Blood transfusion and management

Abstract

BACKGROUND AND OBJECTIVES: Each year, a relevant proportion of whole blood donors is deferred from donation because of low haemoglobin (Hb) levels. Such temporary deferrals are demoralizing, and donors may never return for a donation. Reliable predictions of Hb levels may guide the decision whether donors can be invited for the next donation. In this study, a prediction model was developed for the risk of low Hb levels. MATERIALS AND METHODS: Individual data from 5191 whole blood donors were analysed; 143 donors had a low Hb level. Eleven candidate predictors were considered in logistic regression models to predict low Hb levels. The performance of the prediction model was studied with the receiver operating characteristic (ROC) curve. Internal validity was assessed with a bootstrap procedure. RESULTS: Strong predictors were sex, seasonality, Hb level measured at the previous visit, difference in Hb levels between the previous two visits, time since the previous visit, deferral at the previous visit, and the total number of whole blood donations in the past 2 years. Internal validation showed an area under the ROC curve of 0·87. CONCLUSION: The developed prediction model provides accurate discrimination between donors with low and appropriate Hb levels. The model predictions may be valuable to determine whether donors can be invited for a next donation, or whether some interventions such as postponement of the invitation are warranted. Potentially, this could decrease the number of donor deferrals for low Hb levels.

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References

2007The consequences of temporary deferral on future whole blood donation 1998The effect of short‐term, temporary deferral on future blood donation 2005Hemoglobin screening in prospective blood donors: Comparison of different blood samples and different quantitative methods 2007Seasonal influences on hemoglobin levels and deferral rates in whole‐blood and plasma donors

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2013A systematic review of factors associated with the deferral of donors failing to meet low haemoglobin thresholds 2013External validation and updating of a D utch prediction model for low hemoglobin deferral in I rish whole blood donors 2015Prevalence and determinants of declining versus stable hemoglobin levels in whole blood donors 2013Predicting hemoglobin levels in whole blood donors using transition models and mixed effects models 2012Donor vigilance: What are we doing about it?2016Season and time of day affect capillary blood hemoglobin level and low hemoglobin deferral in blood donors: analysis in a national blood bank 2011Prognostic value of red blood cell parameters and ferritin in predicting deferral due to low hemoglobin in whole blood donors 2021Prediction and impact of personalized donation intervals

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