Trends in Transfusion Transmitted Infections Among Replacement Blood Donors in Karachi, Pakistan

Syed Mohammad Irfan · Jamal Uddin · Hasan Abbas Zaheer · Sadia Sultan · Amjad Baig

21 citations0/0 files storedTurkish Journal of Hematology

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Blood donation and transfusion practices Hepatitis B Virus Studies Hepatitis C virus research

Abstract

OBJECTIVE: To determine the prevalence of Hepatitis-B, Hepatitis-C and Human Immunodeficiency infections in replacement blood donors. MATERIALS AND METHODS: From January 2004 to December 2011, 108,598 apparently healthy donors donated blood at our Blood Bank. Screening was done by Microparticle Enzyme Immuno Assay (MEIA) method on Axsym System (Abbott Diagnostic, USA) and in year 2011 by Chemiluminescent Immunoassay (CIA) method on Architect i2000 (Abbott Diagnostic, USA). From 2010 onward, HIV reactive donors were advised for confirmatory tests and reported back with the results. RESULTS: Of the 108,598 total donors, 108,393 (99.8%) were replacement donors with a mean age of 28.92 (17-55) years. Of this, only 164 (0.15%) were females. Among the replacement donors, 4,906 (4.5%) were found to be reactive for Hepatitis-B, C and Human Immunodeficiency Virus. All the reactive patients, except one, were males. HbsAg was positive in 2,068 (1.90%) and anti-HCV in 2832 (2.61%) donors, while 111 (0.10%) were positive for Human Immunodeficiency Virus. Co-infectivity was observed in 103 (0.09%) cases. The prevalence appeared to be higher in younger age group (17-30 yrs). Only 16.6% cases should be patients returned with results of the confirmatory tests for HIV and were found positive. CONCLUSION: Hepatitis-B and C sero-prevalence in our series of replacement donors appears high compared to most studies from neighboring countries and relatively low in comparison to earlier studies from Pakistan. Prevalence of HIV, however, appears low and turn out of HIV positive cases for confirmatory tests is low. CONFLICT OF INTEREST: None declared.

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2010Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana 2011Moving on from voluntary non‐remunerated donors: who is the best blood donor?2005Estimates of the frequency of HBV, HCV, and HIV infectious donations entering the blood supply in the United Kingdom, 1996 to 2003 2007Infectious pathogens in volunteer and replacement blood donors in Pakistan: a ten-year experience 2009Transfusion-transmissible infections among blood donors in Kathmandu, Nepal 2001Transfusion transmitted diseases 2010Patterns of infections among blood donors in a tertiary care centre: a retrospective study.2009Trends in seroprevalence of hepatitis B, hepatitis C, HIV, and syphilis infections in Iranian blood donors from 2003 to 2005.

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