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High rates of comorbidity between psychopathy and substance use disorders (SUD) have long been recognized. However, the extent to which relationships between SUD and psychopathy extends beyond shared relationship with general antisociality remains undetermined. We examined zero-order and unique relationships between the elements of psychopathy and four categories of SUD; alcohol, cannabis, cocaine, and opioid dependence. The sample consisted of 399 European American and African American male county jail inmates. The relationship between psychopathy and SUD extended beyond general antisociality to core features of the psychopathic personality. Relationships were relatively stable across ethnicity but were more generalized across SUD categories for European American inmates. The relationship between SUD and impulsive and irresponsible behavior was most consistent across categories of SUD; relationships with other elements of psychopathy varied according to category of SUD.
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