Randomized controlled trial: the gold standard or an unobtainable fallacy?

Lars Bondemark · Sabine Ruf

124 citations0/0 files storedEuropean Journal of Orthodontics

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Meta-analysis and systematic reviews Orthodontics and Dentofacial Orthopedics Statistical Methods in Clinical Trials

Abstract

BACKGROUND: This article is the result of a debate at the European Journal of Orthodontics Open Session in 2013 in Reykjavik, Iceland. OBJECTIVE: The aim of this article is to highlight some of the strengths and weakness of clinical orthodontic research, with particular emphasis on randomized controlled trials (RCT). The ultimate aim of improving clinical orthodontic research in general. DESIGN: This article is organized into two sections with arguments for and against RCTs. The backgrounds to evidence-based evaluation and the level or quality of evidence in trials are discussed. The article emphasises what makes high quality clinical research, and gives practical advice including examples of tips and potential pitfalls for those undertaking clinical research. RESULTS AND CONCLUSION: The overriding message is constructive and it is hoped that the article serves as an aid in evaluating, designing, conducting, and reporting clinical research.

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References

2000Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs 2003Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trials 2001Comparison of Evidence of Treatment Effects in Randomized and Nonrandomized Studies 2012What’s in a title? An assessment of whether randomized controlled trial in a title means that it is one

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