Articlehybrid2005

Pup Suckling Is More Rewarding Than Cocaine: Evidence from Functional Magnetic Resonance Imaging and Three-Dimensional Computational Analysis

Craig F. Ferris · Praveen P. Kulkarni · Josie A. Harder · Tara L. Messenger · Marcelo Febo

222 citations0/0 files storedJournal of Neuroscience

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Neuroendocrine regulation and behavior Neurotransmitter Receptor Influence on Behavior Infant Health and Development

Abstract

Nursing has reciprocal benefits for both mother and infant, helping to promote maternal behavior and bonding. To test the "rewarding" nature of nursing, functional magnetic resonance imaging was used to map brain activity in lactating dams exposed to their suckling pups versus cocaine. Suckling stimulation in lactating dams and cocaine exposure in virgin females activated the dopamine reward system. In contrast, lactating dams exposed to cocaine instead of pups showed a suppression of brain activity in the reward system. These data support the notion that pup stimulation is more reinforcing than cocaine, underscoring the importance of pup seeking over other rewarding stimuli during lactation.

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References

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2011Oxytocin and social motivation 2009Does Breastfeeding Protect Against Substantiated Child Abuse and Neglect? A 15-Year Cohort Study 2005Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated with Mother–Pup Bonding during Suckling 2011Borderline personality disorder, mentalization, and the neurobiology of attachment 2009The advantage of social living: Brain neuropeptides mediate the beneficial consequences of sex and motherhood

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