Article2009

Validation of the Hospital Anxiety and Depression Scale for use with multiple sclerosis patients

436 citations0/0 files storedMultiple Sclerosis Journal

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Multiple Sclerosis Research Studies Cancer survivorship and care

Abstract

Detecting clinically significant symptoms of depression and anxiety in medically ill patients using self-report rating scales presents a challenge because of somatic confounders. The Hospital Anxiety and Depression Scale (HADS) was developed with this in mind, but has never been validated for a multiple sclerosis population. Our objective was to validate the HADS for multiple sclerosis patients. Multiple sclerosis patients were interviewed for the presence of major depression (n = 180) and anxiety disorders (n = 140) with the Structured Clinical Interview for DSM-IV disorders. A receiver operating characteristic (ROC) analysis was undertaken to assess which HADS cut-off scores give the best yield with respect to diagnoses of major depression and all anxiety disorders defined by the Structured Clinical Interview for DSM-IV. A threshold score of 8 or greater on the HADS depression subscale provides a sensitivity of 90% and specificity of 87.3% (ROC area under the curve 0.938). The same cut-off score gives a sensitivity of 88.5% and a specificity of 80.7% on the anxiety subscale (ROC area under the curve 0.913), but for generalized anxiety disorder only. The study confirms the usefulness of the HADS as a marker of major depression and generalized anxiety disorder, but not other anxiety disorders, in multiple sclerosis patients.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 436 citations exist upstream.

References

1983The Hospital Anxiety and Depression Scale 1980Diagnostic and Statistical Manual of Mental Disorder Diagnostic and Statistical Manual of Mental Disorder (Third Edition) (DSM III). American Psychiatric Association, 1700 18th Street, NW, Washington, DC 20009, 520 pp, (1980), casebound $52.00, softcover $20.00. The Quick Reference to the Diagnostic Criteria, 267 pp, $10.00. All orders under $53.00 must be prepaid.2005The hospital anxiety and depression rating scale: A cross-sectional study of psychometrics and case finding abilities in general practice

Cited by

2017The validity and reliability of screening measures for depression and anxiety disorders in multiple sclerosis 2012An introduction to Rasch analysis for Psychiatric practice and research 2018Diagnostic and Clinical Utility of the GAD-2 for Screening Anxiety Symptoms in Individuals With Multiple Sclerosis 2015Validity of four screening scales for major depression in MS 2014The 7-Item Generalized Anxiety Disorder Scale as a Tool for Measuring Generalized Anxiety in Multiple Sclerosis 2023One is the loneliest number: Involuntary celibacy (incel), mental health, and loneliness 2016Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory 2018The capability set for work – correlates of sustainable employability in workers with multiple sclerosis

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.