Calculation of Measurement Uncertainty—Why Bias Should Be Treated Separately

Abstract

The concept of measurement uncertainty ( u ), as laid down in the Guide to the Expression of Uncertainty in Measurement (GUM) (1), is gaining more and more importance in the field of laboratory medicine. This concept does not include bias in the calculation of u , but instead requires it to be reported separately. Many are dissatisfied with that approach and try to “fix” GUM by treating bias as a variance and propagating it as such(2). I contend that the calculation of u should adhere to the original GUM document. Assume that an analytical procedure with a CVA …

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