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Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder

Richard Allan Bryant · Kim Louise Felmingham · Thomas J. Whitford · Andrew Haddon Kemp · Anthony S. Peduto · Leanne Maree Williams

138 citations0/0 files storedJournal of Psychiatry and Neuroscience

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Posttraumatic Stress Disorder Research Psychoanalysis and Psychopathology Research Traumatic Brain Injury Research

Abstract

OBJECTIVE: To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume. METHOD: We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n = 13), traumatized control subjects (n = 13) and nontraumatized control subjects (n = 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD. RESULTS: According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume. CONCLUSION: Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains.

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References

1995The structure of negative emotional states: Comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories 2005A Multidimensional Meta-Analysis of Psychotherapy for PTSD 2006Neurocircuitry Models of Posttraumatic Stress Disorder and Extinction: Human Neuroimaging Research—Past, Present, and Future 1990A clinician rating scale for assessing current and lifetime PTSD. The CAPS-1 2005A Functional Magnetic Resonance Imaging Study of Amygdala and Medial Prefrontal Cortex Responses to Overtly Presented Fearful Faces in Posttraumatic Stress Disorder 2006A meta-analysis of structural brain abnormalities in PTSD 1999Neural Correlates of Memories of Childhood Sexual Abuse in Women With and Without Posttraumatic Stress Disorder 2001An fMRI study of anterior cingulate function in posttraumatic stress disorder

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2014Grey matter reduction associated with posttraumatic stress disorder and traumatic stress 2013Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: A diffusion tensor imaging study 2014Abnormal Structure of Fear Circuitry in Pediatric Post-Traumatic Stress Disorder 2010

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