How to read and understand and use systematic reviews and meta‐analyses

Stefan Leucht · Werner Kissling · John M. Davis

65 citations0/0 files storedActa Psychiatrica Scandinavica

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Meta-analysis and systematic reviews Health Sciences Research and Education Clinical practice guidelines implementation

Abstract

OBJECTIVE: Systematic reviews and meta-analyses are increasingly frequently used in the evaluation of medical treatments. This review explains the principles of the methodology, significance and limitations of systematic reviews. METHOD: Short review article. RESULTS: In contrast to conventional reviews, systematic reviews use a structured approach in retrieving, analyzing and interpreting the evidence. A comprehensive search strategy is applied to identify all relevant trials. Study selection and data extraction is performed independently by at least two reviewers. The data are usually synthesized in a meta-analysis applying statistical methods to examine homogeneity. Funnel plots and other statistical methods are applied to detect publication bias. CONCLUSION: Due to the enormous amount of scientific information published every year, systematic reviews and meta-analyses have become indispensable methods for the evaluation of medical treatments.

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References

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