Articlegold2011

Microstructure Abnormalities in Adolescents with Internet Addiction Disorder

Kai Yuan · Wei Qin · Guihong Wang · Fang Zeng · Liyan Zhao · Xuejuan Yang +7 more

367 citations0/0 files storedPLoS ONE

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Impact of Technology on Adolescents Advanced Neuroimaging Techniques and Applications Sexuality, Behavior, and Technology

Abstract

BACKGROUND: Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD. CONCLUSIONS: Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.

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References

1998Internet Addiction: The Emergence of a New Clinical Disorder 2000Incidence and correlates of pathological Internet use among college students 2003Executive Attention, Working Memory Capacity, and a Two-Factor Theory of Cognitive Control 2001Modification in the Proposed Diagnostic Criteria for Internet Addiction 1977The ecology of adolescent activity and experience 2005A Review of the Research on Internet Addiction 2008Brain activities associated with gaming urge of online gaming addiction 2005Internet Addiction: A Review of Current Assessment Techniques and Potential Assessment Questions

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