Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photon emission computerized tomography

Stephan Volk · Stephen Kaendler · Roxane Weber · Klaus Georgi · Frank D. Maul · Andreas Hertel +2 more

44 citations0/0 files storedActa Psychiatrica Scandinavica

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Sleep and Work-Related Fatigue Treatment of Major Depression Sleep and Wakefulness Research

Abstract

HMPAO-single photon emission computerized tomography (SPECT) is a useful technique in studying cerebral blood flow (CBF). This method is suitable to evaluate the differences of CBF with reference to total sleep deprivation (TSD) within 24 h because of the short half-life of the radiopharmaceutical compound. In the present study, CBF before and after TSD was analysed in patients suffering from major depression. The morning before and after TSD, Tc-HMPAO-SPECT was performed in 20 patients. Hamilton Rating Scale for Depression scores and subjective ratings were obtained daily. Eleven patients responded to TSD; 9 were nonresponders. The main finding was a significant left temporal and mainly right parietal increase of CBF, which was observed in the responders only. CBF values and the severity of depression correlated inversely.

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1960A RATING SCALE FOR DEPRESSION 1959THE ASSESSMENT OF ANXIETY STATES BY RATING 1988Biologische Psychiatrie

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