Article2008

Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients

Michiko Nakazato · Kate Tchanturia · Ulrike H Schmidt · Iain C. Campbell · Janet L. Treasure · David Andrew Collier +2 more

75 citations0/0 files storedPsychological Medicine

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Eating Disorders and Behaviors Nutrition, Health and Food Behavior Regulation of Appetite and Obesity

Abstract

BACKGROUND: Studies of patients with anorexia nervosa (AN) have shown that they do not perform well in set-shifting tasks but little is known about the neurobiological correlates of this aspect of executive function. The aim of this study was to measure serum brain-derived neurotrophic factor (BDNF) and to establish whether set-shifting difficulties are present in people with current AN and in those recovered from AN, and whether serum BDNF concentrations are correlated with set-shifting ability. METHOD: Serum BDNF concentrations were measured in 29 women with current AN (AN group), 18 women who had recovered from AN (ANRec group) and 28 age-matched healthy controls (HC group). Set-shifting was measured using the Wisconsin Card Sorting Test (WCST). Eating-related psychopathology and depressive, anxiety and obsessive-compulsive symptomatology were evaluated using the Eating Disorder Examination Questionnaire (EDEQ), the Hospital Anxiety and Depression Scale (HADS), and the Maudsley Obsessive-Compulsive Inventory (MOCI) respectively. RESULTS: Serum BDNF concentrations (mean+/-s.d.) were significantly lower in the AN group (11.7+/-4.9 ng/ml) compared to the HC group (15.1+/-5.5 ng/ml, p=0.04) and also compared to the ANRec group (17.6+/-4.8 ng/ml, p=0.001). The AN group made significantly more errors (total and perseverative) in the WCST relative to the HC group. There was no significant correlation between serum BDNF concentrations and performance on the WCST. CONCLUSIONS: Serum BDNF may be a biological marker for eating-related psychopathology and of recovery in AN. Longitudinal studies are needed to explore possible associations between serum BDNF concentrations, illness and recovery and neuropsychological traits.

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1983The Hospital Anxiety and Depression Scale 1994Assessment of eating disorders: Interview or self‐report questionnaire?1995Neuropsychological assessment.1977Obsessional-compulsive complaints 2007A systematic review and meta-analysis of set-shifting ability in eating disorders 2001Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision) (DSM–IV–TR) Washington, DC: American Psychiatric Association 2000. 943 pp. £39.99 (hb). ISBN 0 89042 025 4 2005Is Impaired Set-Shifting an Endophenotype of Anorexia Nervosa?2004Set shifting in anorexia nervosa: an examination before and after weight gain, in full recovery and relationship to childhood and adult OCPD traits

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