Articlebronze2009

Common and Distinct Amygdala-Function Perturbations in Depressed vs Anxious Adolescents

Katja Beesdo‐Baum · Jennifer Y. F. Lau · Amanda E. Guyer · Erin B. Tone · Christopher S. Monk · Eric E. Nelson +6 more

250 citations0/0 files storedArchives of General Psychiatry

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Neural and Behavioral Psychology Studies

Abstract

CONTEXT: Few studies directly compare amygdala function in depressive and anxiety disorders. Data from longitudinal research emphasize the need for such studies in adolescents. OBJECTIVE: To compare amygdala response to varying attention and emotion conditions among adolescents with major depressive disorder (MDD) or anxiety disorders, relative to adolescents with no psychopathology. DESIGN: Case-control study. SETTING: Government clinical research institute. PARTICIPANTS: Eighty-seven adolescents matched on age, sex, intelligence, and social class: 26 with MDD (14 with and 12 without anxiety disorders), 16 with anxiety disorders but no depression, and 45 without psychopathology. MAIN OUTCOME MEASURES: Blood oxygen level-dependent signal in the amygdala, measured by means of event-related functional magnetic resonance imaging. During imaging, participants viewed facial expressions (neutral, fearful, angry, and happy) while attention was constrained (afraid, hostility, and nose-width ratings) or unconstrained (passive viewing). RESULTS: Left and right amygdala activation differed as a function of diagnosis, facial expression, and attention condition both when patients with comorbid MDD and anxiety were included and when they were excluded (group x emotion x attention interactions, P < or = .03). Focusing on fearful face-viewing events, patients with anxiety and those with MDD both differed in amygdala responses from healthy participants and from each other during passive viewing. However, both MDD and anxiety groups, relative to healthy participants, exhibited similar signs of amygdala hyperactivation to fearful faces when subjectively experienced fear was rated. CONCLUSIONS: Adolescent MDD and anxiety disorders exhibit common and distinct functional neural correlates during face processing. Attention modulates the degree to which common or distinct amygdala perturbations manifest in these patient groups, relative to healthy peers.

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References

2005Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication 1997Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data 2004Cognitive Vulnerability to Emotional Disorders 1999The Structure of Common Mental Disorders 1998The Risk for Early-Adulthood Anxiety and Depressive Disorders in Adolescents With Anxiety and Depressive Disorders 2001Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study 2000Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study 2006Offspring of Depressed Parents: 20 Years Later

Cited by

2011Attention biases, anxiety, and development: toward or away from threats or rewards?2016Comorbid Anxiety and Depressive Symptoms in Children and Adolescents 2020Research Review: Pediatric anxiety disorders – what have we learnt in the last 10 years?2012A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder.

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