Pathological gambling in Parkinson disease is reduced by amantadine

Astrid Thomas · Laura Bonanni · Francesco Gambi · Angelo Di Iorio · MARCO C. ONOFRJ

235 citations0/0 files storedAnnals of Neurology

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Gambling Behavior and Treatments Parkinson's Disease Mechanisms and Treatments Obsessive-Compulsive Spectrum Disorders

Abstract

To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson disease (PD), 17 PD patients with PG were randomly selected for a double-blind crossover study with amantadine 200mg/day versus placebo and an open follow-up. Assessments included PG-specific scales (Yale-Brown Obsessive-Compulsive Scale for PG, Gambling-Symptom Assessment Scale, South Oaks Gambling Screen) and assessment of expenditures and time spent gambling. Amantadine abolished or reduced PG in all treated patients, as confirmed by scale score and daily expenditure reduction. Amantadine might be useful to treat PG. The effect of amantadine, acting as an antiglutamatergic agent, also opens new insights into the pathogenesis of PG.

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References

1987The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers 2009The Gambling Symptom Assessment Scale (G-SAS): A reliability and validity study 2005Reliability and Validity of the Pathological Gambling Adaptation of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS)

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2015Behavioural addiction—A rising tide?2014Treatment of Gambling Disorders 2014Pharmacological Treatments in Gambling Disorder: A Qualitative Review 2011Pathological Gambling: Neuropsychopharmacology and Treatment 2017Treatment modalities for patients with gambling disorder 2020The Cambridge Handbook of Substance and Behavioral Addictions 2020Prevention and Treatment of Compulsive Buying Disorder

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