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The place of the newer penicillins in the treatment of any other infections thani staphylococcal is more doubtful.Penicillin G exceeds all other penicillins in activity against all other bacteria (except two uncommon species of Proteus), the differences being often wide.The nearest approach to the activity of penicillin G against important pathogenic organisms such as haemolytic streptococci and pneumococci is that of penicillin V, which may therefore reasonably claim to retain its place in the oral treatment of sufficiently sensitive infections. SummaryThe minimum concentrations of four penicillins inhibiting the growth of a variety of pathogenic bacteria have been determined, and the differences in activity so revealed are briefly discussed.I am indebted to Beecham Research Laboratories for kindly furnishing supplies of broxil and celbenin; to Eli Lilly and Co. for supplies of pure potassium penicillin V; to Dr. C
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