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The organism-environment interrelationship is at the heart of developmental psychology and psychopathology. This chapter considers some of the obstacles that interfere with a greater adoption of probabilistic epigenesis in individual research. It describes the used probabilistic epigenesis model to organize existing research on elevated rates of cigarette smoking among attention-deficit hyperactivity disorder (ADHD) youth, as well as to create testable predictions for future research. An essential element of the probabilistic-epigenetic perspective (and of systems models in general) is an emphasis on the coordination or coaction of influences over time. The chapter also briefly considers how a probabilistic-epigenetic perspective relates to two major themes in developmental research: prevention science and the study of risk and resilience. The ongoing challenge is to distill the ideas common to modern developmental metatheory in a way that guides individual research studies.
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