Enhanced Cellular Immune Response in Women With PTSD Related to Childhood Abuse

Margaret M. Altemus · Marylène Cloître · Firdaus S. Dhabhar

122 citations0/0 files storedAmerican Journal of Psychiatry

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Posttraumatic Stress Disorder Research Child Abuse and Trauma Stress Responses and Cortisol

Abstract

OBJECTIVE: Disturbed regulation of both the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenomedullary system in posttraumatic stress disorder (PTSD) suggests that immune function, which is modulated by these systems, also may be dysregulated in individuals with PTSD. METHOD: Delayed-type hypersensitivity skin test responses were measured in 16 women with PTSD due to childhood sexual or physical abuse and 15 women who did not have a history of abuse, other trauma, or psychiatric disorders. HPA axis activity was assessed by examination of circadian salivary cortisol levels and a single time point measurement of plasma cortisol. RESULTS: Delayed-type hypersensitivity was enhanced in women with PTSD. Cortisol measures did not differ between PTSD and healthy comparison subjects. CONCLUSIONS: These results suggest that cell-mediated inflammatory reactions are greater in individuals with PTSD.

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1995The development of a Clinician-Administered PTSD Scale 1999Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events 2000Physician-diagnosed medical disorders in relation to PTSD symptoms in older male military veterans.1997Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder 1998PSYCHONEUROENDOCRINOLOGY OF POST-TRAUMATIC STRESS DISORDER

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