Changes in the quality of life of patients receiving antidepressant medication in primary care: Validation of the WHOQOL–100

Suzanne M. Skevington

137 citations0/0 files storedThe British Journal of Psychiatry

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Health Systems, Economic Evaluations, Quality of Life Treatment of Major Depression Health and Well-being Studies

Abstract

BACKGROUND: The study arises from the need for good quality of life (QOL) assessment and a new comprehensive generic QOL profile for cross-cultural use. AIMS: To examine changes in the QOL of patients receiving antidepressants from a general practitioner, and to assess the validity and sensitivity of a new QOL measure, the World Health Organization Quality of Life Assessment (100-item version) (WHOQOL-100). METHOD: Patients with moderate depression (n = 106) completed the WHOQOL-100 and Beck Depression Inventory at the start of treatment and again after 6 weeks. RESULTS: Depression decreased significantly over 2 months and 74% reported feeling better. WHOQOL-100 scores increased in 24 of the 25 facets, demonstrating that QOL improves significantly in the 8 weeks following the start of antidepressant treatment. It also shows the instrument's validity and sensitivity to changes in clinical condition. CONCLUSIONS: The UK WHOQOL-100 is confirmed as excellent to good. Antidepressants significantly and comprehensively improve QOL.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 1995The World Health Organization quality of life assessment (WHOQOL): Position paper from the World Health Organization 1998The World Health Organization quality of life assessment (WHOQOL): Development and general psychometric properties 1994Development of the WHOQOL: Rationale and Current Status 1999Measuring quality of life in britain 1993The costs of depression

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