Article2006

Prospective comparison of high‐dose plateletpheresis with the latest apheresis systems on the same donors

Susanne Maria Picker · Stela Radojska · Birgit Sybille Gathof

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Blood donation and transfusion practices Blood transfusion and management Trauma, Hemostasis, Coagulopathy, Resuscitation

Abstract

BACKGROUND: To improve productivity of automated platelet (PLT) collection, the industry has introduced new instruments or modifications to existing equipment. STUDY DESIGN AND METHODS: With the same 8 donors for double (DDC) and triple-dose PLT collection (TDC), the Baxter Amicus (AM), the Haemonetics MCS Plus (MCS+), and the Gambro Trima Accel (TA) were evaluated focusing on yield, duration, and citrate donor load. Target endpoints were set at 5.5 x 10(11) to 6.0 x 10(11) PLTs (DDC) and 7.5 x 10(11) to 8.0 x 10(11) PLTs (TDC) in up to 100 and 120 minutes' donation time, respectively. RESULTS: TA was the most efficient system (74.5 +/- 3.9%) with significant differences from AM (71.1 +/- 3.9%; p = 0.028) and MCS+ (64.0 +/- 7.7%; p = 0.002). TA had advantages over AM for collection rate (10.9 x 10(9) +/- 2.2 x 10(9) vs. 10.1 x 10(9) +/- 1.5 x 10(9) PLTs/min; p = 0.382), whole blood processed (3928 +/- 611 mL vs. 4219 +/- 727 mL; p = 0.382), and time to obtain an established standard dose (TSD 2.5(EU), 30.2 +/- 5.6 vs. 37.7 +/- 5.5 min; TSD 3.5(US), 42.2 +/- 7.8 min vs. 52.7 +/- 7.7 min; p = 0.015), whereas AM was slightly superior in PLT yield (2.81 x 10(11) +/- 0.21 x 10(11) vs. 2.76 x 10(11) +/- 0.31 x 10(11)/unit; p = 0.645). Owing to the lowest draw (42.3 +/- 3.2 mL/min; p < 0.001) and collection rates (6.0 x 10(11) +/- 1.5 x 10(11)/min; p = 0.021), MCS+ was the slowest significantly (p < 0.001) but compensated with fewer citrate reactions owing to lower citrate infusion rates (0.78 +/- 0.11 mL/min/L; p = 0.028). CONCLUSION: High-dose plateletpheresis was performed efficiently and safely with all three instruments. AM had advantages in PLT yield, and MCS+, in donor comfort. TA was the fastest in obtaining an established standard dose and, because of this advantage, the machine with the highest practical impact in routine use.

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References

2005A randomized crossover trial comparing three plateletpheresis machines 2002National audit of citrate toxicity in plateletpheresis donors 1997Plateletapheresis with a next generation blood cell separator 1999Plateletpheresis efficiency: a comparison of the Spectra LRS and AMICUS separators 2005Multicomponent apheresis blood collection in the United States: Current status and future directions 2005Frequently used plateletpheresis techniques result in variable target yields and platelet recruitment of donors 2003First comparison of productivity and citrate donor load between the Trima® version 4 (dual‐stage filler) and the Trima Accel® (single‐stage filler) in the same donors

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2012Donor safety in triple plateletpheresis: results from the German and Austrian Plateletpheresis Study Group multicenter trial 2009Paired crossover study of two plateletpheresis systems concerning platelet product quality and donor comfort 2020Analysis of Donor Safety in High Yield Plateletpheresis Procedures: An Experience from Tertiary Care Hospital in South India 2013The relationship of platelet yield, donor’s characteristic and apheresis instruments in China 2009Feasibility and safety of triple dose platelet collection by apheresis

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