Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women

Marilyn C. Cornelis · Eric B. Rimm · Gary C. Curhan · Peter Kraft · Frank B. Hu · Rob M. van Dam

116 citations0/0 files storedObesity

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Eating Disorders and Behaviors Genetic Associations and Epidemiology Nutrition, Genetics, and Disease

Abstract

OBJECTIVE: Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward-seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined. METHODS: Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome-wide scans and a genetic-risk score (GRS) derived from 32 obesity-loci was calculated. RESULTS: The GRS was positively associated with emotional and uncontrolled eating (P<0.002). In exploratory analysis, BMI-increasing variants of MTCH2, TNNI3K, and ZC3H4 were positively associated with emotional eating and those of TNNI3K and ZC3H4 were positively associated with uncontrolled eating. The BMI-increasing variant of FTO was positively and those of LRP1B and TFAP2B were inversely associated with cognitive restraint. These associations for single SNPs were independent of BMI but were not significant after multiple-testing correction. CONCLUSIONS: An overall genetic susceptibility to obesity may also extend to eating behaviors. The link between specific loci and obesity may be mediated by eating behavior but larger studies are warranted to confirm these results.

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References

2000Psychometric properties and factor structure of the Three-Factor Eating Questionnaire (TFEQ) in obese men and women. Results from the Swedish Obese Subjects (SOS) study 2004The Three-Factor Eating Questionnaire-R18 Is Able to Distinguish among Different Eating Patterns in a General Population 1993The effects of dieting on eating behavior: A three-factor model.2005Genetic and environmental influences on eating behavior: the Swedish Young Male Twins Study 2002Eating behavior correlates of adult weight gain and obesity in healthy women aged 55–65 y 2010Risk factors and prodromal eating pathology 2003Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study 2007Construct validation of the Restraint Scale in normal-weight and overweight females

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