Discovery of DNA Polymerase

Abstract

DNA polymerase, an enzyme discovered in 1955, has the remarkable capacity to catalyze the template-directed synthesis of DNA (1, 2). The discovery of DNA polymerase has contributed in major ways to our present day understanding of how DNA is replicated and repaired and how it is transcribed. It also permitted the development of PCR and DNA sequencing, upon which much of modern biotechnology is based. In this article, I wish to recount how the discovery of the first DNA polymerase, DNA polymerase I of Escherichia coli, came about.

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