Opioid‐mediation of separation distress in 10‐day‐old rats: Reversal of stress with maternal stimuli

Priscilla Kehoe · Elliott M. Blass

201 citations0/0 files storedDevelopmental Psychobiology

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Neuroendocrine regulation and behavior Neuropeptides and Animal Physiology Infant Health and Development

Abstract

A relationship between distress vocalizations, response to nociception and their opioid mediation in 10-day-old maternally isolated rat pups was established. The comforting effects of several classes of biological stimuli were examined. Short-term (5 min) isolation from mother, siblings and nest caused a significant analgesic response to heat (48 degrees C) relative to nonisolated siblings. Morphine administration markedly increased heat escape latencies and decreased distress vocalizations during isolation. Naltrexone, an opioid antagonist, had the opposite effect; escape latencies were halved and distress vocalizations doubled. Contact with an anesthetized female, dam or virgin, immediately reduced both analgesia and vocalizations. Home-bedding was only effective after 5 min exposure, whereas clean bedding did not reduce isolation-induced behaviors. These results are discussed in terms of infant learning and motivation under natural circumstances.

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1988Milk-induced analgesia and comforting in 10-day-old rats: Opioid mediation 2008Variation at the mu-opioid receptor gene ( OPRM1 ) influences attachment behavior in infant primates 2007Panic, suffocation false alarms, separation anxiety and endogenous opioids 2013The Anatomy of Motivation: An Evolutionary-Ecological Approach 1990Suckling: Determinants, changes, mechanisms, and lasting impressions.1995Opiate systems in mother and infant primates coordinate intimate contact during reunion

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