Measurement of cumulative physiological dysregulation in an older population

Christopher L. Seplaki · Noreen Goldman · Maxine Weinstein · Yu-Hsuan Lin

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Health disparities and outcomes Aging, Health, and Disability Chronic Disease Management Strategies

Abstract

The allostatic load framework postulates that an important pathway connecting the social environment with health involves biological responses to stressful stimuli and the subsequent dysregulation of interrelated physiological systems. We formulate a new measure for cumulative physiological dysregulation using a grade of membership model estimated with biodemographic data from a national sample of older Taiwanese persons. We investigate associations between the measure and physical, psychological, and cognitive function. The results provide insights into the relationships between a set of biological profiles and various health outcomes, identify limitations of earlier approaches, and underscore next steps in the development of improved for mulations of physiological dysregulation.

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References

1977The CES-D Scale 1994Neuropsychological Assessment 1993Two Shorter Forms of the CES-D Depression Symptoms Index 2001Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging 1997Price of Adaptation—Allostatic Load and Its Health Consequences 1999Cross-validation of a short form of the CES-D in Chinese elderly 2002Social Relationships, Gender, and Allostatic Load Across Two Age Cohorts 2002Allostatic load as a predictor of functional decline

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