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The aim of this article is to study the relationship between Bruno Latour’s theories and semiotics. In particular the article compares Latour’s concepts to those of the linguist A.J. Greimas. From Latour’s earliest texts in science studies onwards, semiotics has been a basic theoretical tool. As the article will show, Latour privileges the autonomy of language in order to avoid the ascription of substance to human and non-human actors. It is within this autonomous field that his general associology based on trials of strength can come into play. Furthermore, the article analyses Latour’s theories concerning the gradual emergence of actors, circulation of references and technical mediation. Finally, the article tries to show how Latour’s approach reaches a limit when it comes to the study of the settings of social action. A way out of this problem is sketched while at the same time remaining within a semiotic universe. *Key words*: Bruno Latour, science studies, semiotics
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