Article1998

Noradrenergic control of central oxytocin release during lactation in rats

69 citations0/0 files storedAmerican Journal of Physiology-Endocrinology and Metabolism

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Neuroendocrine regulation and behavior Neuropeptides and Animal Physiology Hypothalamic control of reproductive hormones

Abstract

Noradrenergic systems regulate the systemic release of oxytocin (OT) in lactating rats. However, a role for norepinephrine (NE) in release of OT within the magnocellular nuclei during suckling has not been established. These studies were designed to determine 1) if suckling induces NE release in the supraoptic (SON) and paraventricular (PVN) nuclei of conscious rats and 2) the role of NE in the central, intranuclear release of OT within these nuclei. Female Holtzman rats were implanted with microdialysis probes adjacent to the PVN or SON on lactation days 8-12. The following day, the pups were isolated from the dams for 4 h. Microdialysis probes were perfused with artificial cerebrospinal fluid (ACSF) or with ACSF containing an alpha- or a beta-adrenergic receptor antagonist. Dialysate was collected before, during, and after suckling and analyzed for NE or OT. In an additional experiment, an alpha- or beta-adrenergic agonist was administered via the microdialysis probes into the PVN in nonsuckled, lactating rats. Extracellular NE increased in the PVN during suckling but was not detectable in the SON. OT concentrations in dialysates from the PVN and SON significantly increased during suckling. Blockade of either alpha-(in both PVN and SON) or beta- (PVN) adrenergic receptors prevented the suckling-induced increase in central OT release. OT release was increased in nonsuckled, lactating rats by central application of either an alpha- or beta-adrenergic agonist. These data demonstrate that intranuclear NE release is increased in the PVN by suckling and that subsequent stimulation of both alpha- and beta-noradrenergic receptors mediates intranuclear OT release.

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References

1993Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: A microdialysis study 1984Release of oxytocin and vasopressin by magnocellular nuclei in vitro : specific facilitatory effect of oxytocin on its own release 2008Simultaneous Microdialysis in Blood and Brain: Oxytocin and Vasopressin Release in Response to Central and Peripheral Osmotic Stimulation and Suckling in the Rat 1989Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats 1992Neurochemical Regulation of Oxytocin Secretion in Lactation*1996Oxytocin Released within the Supraoptic Nucleus of the Rat Brain by Positive Feedback Action is Involved in Parturition‐Related Events 1994Systemic Osmotic Stimulation Increases Vasopressin and Oxytocin Release Within the Supraoptic Nucleus 1992Oxytocin, amino acid and monoamine release in the region of the medial preoptic area and bed nucleus of the stria terminalis of the sheep during parturition and suckling

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2020Somato‐dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation 2001Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression 2018

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