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Abstract In this cluster randomized trial (N 1060), we tested the impact of financial incentives (£5 voucher vs. £200 lottery) framed as a gain or loss to promote Chlamydia screening in students aged 18–24 years, mimicking the standard outreach approach to student in halls of residence. Compared to the control group (1.5%), the lottery increased screening to 2.8 % and the voucher increased screening to 22.8%. Incentives framed as gains were marginally more effective (10.5%) than loss-framed incentives (7.1%). This work contributes to the literature by testing the predictive val-idity of Prospect Theory to change health behavior in the field.
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