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Innovation system approach, as a result of change in understanding of the innovation process, can be examined in sectoral, regional and national level. Regional innovation system initiatives which aim at increasing the innovative capacity regions have been implemented in the West for a long time. Examining the successful cases and defining the success factors of past experiences will shed light on new efforts on establishing regional innovation systems. In Turkey, efforts of building regional innovation systems have recently increased. This study aims to provide several policy recommendations on the successful formation and implementation of regional innovation systems with the help of Western experiences. In the study, the concept of regional innovation system is examined in detail in terms of its emergence, elements, success conditions and policies. As a result of the study, it is concluded that four factor became prominent in building regional innovation system and gaining regional competitive advantage. These factors are (i) region-specific sectoral clusters, (ii) local and global networks, (iii) education/science infrastructure and links with university, and (iv) entrepreneurship supporting policies.
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