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It is becoming increasingly clear that the initial signs of age-associated changes in health appear well before old age, and often develop in early adulthood.1 Further, there is growing evidence that risk factors of late-life chronic disease, disability and cognitive decline can be traced to early parts of the lifespan.2–4 These new developments in our understanding of health in old age call for a renewed focus on early prevention of age-related decline in health and on promotion of healthy ageing at population level. The Copenhagen Aging and Midlife Biobank (CAMB) has been established to contribute to the knowledge on the life course determinants of age-associated changes in health and function in mid and late life, and it is designed with particular emphasis on the early stages of the ageing process.5 Existing Danish longitudinal population studies with cognitive and biological data are limited by small baseline sample sizes. This has resulted in severe statistical power problems due to natural sample attrition as the participants reach high age. Therefore, larger mid-life samples are needed to obtain reasonable sample sizes in old age. Moreover, no available Danish databases allow analyses of the combined influence of biological, cognitive, physical and social factors in childhood, adolescence and early adulthood on early indicators of ageing. An important contribution from CAMB, compared with existing life-course cohorts from, for example, the UK, is the possibility of linking the entire cohort, including non-respondents, to detailed register-based information from 1980 onwards.
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