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A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia
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A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia (2016)A Phase II Dose-Ranging Study Evaluating …Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials (2014)Suvorexant in Patients With I…Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial (2014)Safety and efficacy of suvore…The Orexin Antagonist SB-649868 Promotes and Maintains Sleep in Men with Primary Insomnia (2012)The Orexin Antagonist SB-6498…Quality of life in patients suffering from insomnia. (2012)Quality of life in patients s…Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial (2012)Orexin Receptor Antagonism, a…Orexin receptor antagonism for treatment of insomnia (2012)Orexin receptor antagonism fo…Chronic insomnia (2012)Chronic insomniaThe Association between Insomnia Severity and Healthcare and Productivity Costs in a Health Plan Sample (2011)The Association between Insom…Hyperarousal and insomnia: State of the science (2009)Hyperarousal and insomnia: St…Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation (2008)Insomnia: Prevalence, Impact,…Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults (2008)Clinical Guideline for the Ev…The American Academy of Sleep Medicine (AASM) Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications (2007)The American Academy of Sleep…A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects (1968)A manual for standardized ter…Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis (2023)Dual orexin receptor antagoni…Orexin Receptor Antagonists and Insomnia (2022)Orexin Receptor Antagonists a…ECDEU Assessment Manual for Psychopharmacology (1976)Validation of the Insomnia Severity Index as an outcome measure for insomnia research (2001)Diagnostic and Statistical Manual of Mental Disorders (2013)Review of Safety and Efficacy of Sleep Medicines in Older Adults (2016)S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen (2017)Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery (2018)The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults (2011)Pharmacologic Treatment of Insomnia Disorder: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians (2016)The assessment and management of insomnia: an update (2019)Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials (2022)Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR ) (2010)Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? (2014)A cognitive model of insomnia (2002)Epidemiology of insomnia: what we know and what we still need to learn (2002)The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis (2015)Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline (2017)Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment (2019)A Behavioral Perspective on Insomnia Treatment (1987)Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults (1996)Cumulative Sleepiness, Mood Disturbance, and Psychomotor Vigilance Performance Decrements During a Week of Sleep Restricted to 4–5 Hours per Night (1997)Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder (2013)Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases (2016)Epidemiology of Insomnia (2022)Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? (1989)The International Classification of Sleep Disorders (1991)Environmental Determinants of Insufficient Sleep and Sleep Disorders: Implications for Population Health (2018)Sex Differences in Insomnia: from Epidemiology and Etiology to Intervention (2018)The economic cost of inadequate sleep (2018)The World Health Organization quality of life assessment (WHOQOL): Position paper from the World Health Organization (1995)The World Health Organization's WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group (2004)Australasian Sleep Association position statement regarding the use of psychological/behavioral treatments in the management of insomnia in adults (2017)Effects of cognitive behavioral therapy for insomnia (CBT-I) on quality of life: A systematic review and meta-analysis (2022)Estimation of the global prevalence and burden of insomnia: a systematic literature review-based analysis (2025)Cohort Profile: The Study of Health in Pomerania (2010)Sleep and mental disorders: A meta-analysis of polysomnographic research. (2016)AASM Scoring Manual Updates for 2017 (Version 2.4) (2017)The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research (1989)Impact of sleep debt on metabolic and endocrine function (1999)Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan (2004)Insomnia disorder (2015)Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis (2017)
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References

  • 1968A manual for standardized terminology, techniques and scoring system for sleep stages in human subjects11,772 cited
  • 2007The American Academy of Sleep Medicine (AASM) Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications6,529 cited
  • 2008Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults1,940 cited
  • 2012Chronic insomnia975 cited
  • 2009Hyperarousal and insomnia: State of the science914 cited
  • 2014Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial519 cited
  • 2012Orexin receptor antagonism for treatment of insomnia322 cited
  • 2014Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials301 cited
  • 2008Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation297 cited
  • 2012Quality of life in patients suffering from insomnia.215 cited
  • 2012Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial126 cited
  • 2011The Association between Insomnia Severity and Healthcare and Productivity Costs in a Health Plan Sample122 cited
  • 2012The Orexin Antagonist SB-649868 Promotes and Maintains Sleep in Men with Primary Insomnia86 cited

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  • 2022Orexin Receptor Antagonists and Insomnia38 cited
  • 2023Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis36 cited