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In this paper the process of the business development of spin-off companies from universities is described. The authors discuss each phase of development (awareness, feasibility, start-up, growth and maturity) and provide examples of each phase. They describe in particular the example of the University of Twente and its spin-off programme, TOP (Temporary Entrepreneurial Positions). Secondly, they focus on university spin-off programmes: what are the arguments against and in favour of such initiatives? The arguments that led the University of Twente to favour investment in spin-off programmes are discussed. The final section of the paper concerns the EU-supported UNISPIN project, a systematic approach to university spin-off development throughout all member states of the European Union.
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