Review2015

Insomnia and Somnolence Associated With Second-Generation Antidepressants During the Treatment of Major Depression

Siegfried Alberti · Alberto Chiesa · Costanza Andrisano · Alessandro Serretti

59 citations0/0 files storedJournal of Clinical Psychopharmacology

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Abstract

BACKGROUND: Sleep reduction or enhancement is frequently observed with second-generation antidepressant treatments, and they can be beneficial or harmful depending on the symptom profile of each subject. Nevertheless, relatively little attention has been given so far to rank those effects across compounds. The aim of this meta-analysis is to provide quantitative data about short-term rates of insomnia and somnolence associated with 14 second-generation antidepressants during the treatment of major depression. METHODS: A literature search and a search of unpublished documents were performed. Eligible studies focusing on MD patients treated with second-generation antidepressants were entered in the analysis. Our primary outcome measures were insomnia and somnolence rates induced by antidepressants as compared with those associated with placebo. Sensitivity analyses were carried out as well. RESULTS: Ten second-generation antidepressants showed higher rates of insomnia than placebo. The highest incidence was found for bupropion and desvenlafaxine. Agomelatine was the only antidepressant with a lower likelihood of inducing insomnia than placebo. Eleven antidepressants were associated with higher rates of somnolence than placebo. Fluvoxamine and mirtazapine showed the highest frequency of somnolence. Bupropion induced somnolence to a lower extent than placebo. Sensitivity analyses showed a degree of variation of those findings. DISCUSSION: Antidepressants are associated with different insomnia and somnolence rates, mainly depending on their mechanisms of action. Despite some limitations, we underscore that the treatment-emergent insomnia and/or somnolence are frequent, and they could be used in clinical practice to face the specific needs of each patient.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 59 citations exist upstream.

References

1997Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study 1995Empirical Evidence of Bias 1995Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials 2005Epidemiology of Major Depressive Disorder 2005Antidepressants and their effect on sleep 2003Antidepressant-related deaths and antidepressant prescriptions in England and Wales, 1998–2000 2005Insomnia improvement during antidepressant treatment andCLOCK gene polymorphism 1997Down‐rating lifetime suicide risk in major depression

Cited by

2018Drug-Induced Insomnia and Excessive Sleepiness

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.